Cell death discovery suggests new ways to protect female fertility

ScienceDaily (Sep. 21, 2012) ? Melbourne researchers have identified a new way of protecting female fertility, offering hope to women whose fertility may be compromised by the side-effects of cancer therapy or by premature menopause.

The researchers, from the Walter and Eliza Hall Institute, Monash University and Prince Henry's Institute of Medical Research, made the discovery while investigating how egg cells die.

They found that two specific proteins, called PUMA and NOXA, cause the death of egg cells in the ovaries. The finding may lead to new strategies that protect women's fertility by blocking the activity of these two proteins.

Associate Professor Clare Scott from the Walter and Eliza Hall Institute said the research showed that when the DNA of egg cells is damaged following exposure to radiation or chemotherapy, such as that received during some cancer treatments, PUMA and NOXA trigger the death of the damaged eggs. This egg cell death causes many female cancer patients to become infertile.

"PUMA and NOXA can trigger cell death, and have been found to be necessary for the death of many different cell types in response to DNA damage," Associate Professor Scott, who is also an oncologist at The Royal Melbourne and Royal Women's Hospitals, said. "This removal of damaged cells is a natural process that is essential to maintaining health but, for women undergoing cancer treatment, can be devastating when it leads to infertility."

Associate Professor Scott, Dr Ewa Michalak and Professor Andreas Strasser from the Walter and Eliza Hall Institute, together with Associate Professor Jeffrey Kerr from Monash University, and Dr Karla Hutt and Professor Jock Findlay from Prince Henry's Institute of Medical Research, focused their studies on egg cells called primordial follicle oocytes, which provide each woman's lifetime supply of eggs. Low numbers of these egg cells can also be a cause of early menopause. Their findings are published online this week in the journal Molecular Cell.

Associate Professor Jeff Kerr said that when these egg-producing cells were missing the PUMA protein, they did not die after being exposed to radiation therapy. "This might ordinarily be cause for concern because you want damaged egg cells to die so as not to produce abnormal offspring," he said. "To our great surprise we found that not only did the cells survive being irradiated, they were able to repair the DNA damage they had sustained and could be ovulated and fertilized, producing healthy offspring. When the cells were also missing the NOXA protein, there was even better protection against radiation."

"We were very excited to see healthy offspring could be produced from these cells," Associate Professor Scott said. "It means that in the future, medications that block the function of PUMA could be used to stop the death of egg cells in patients undergoing chemotherapy or radiotherapy. Our results suggest that this could maintain the fertility of these patients."

A joint leader of the study, Professor Jock Findlay, head of the Female Reproductive Biology Group at Prince Henry's Institute, said the study could also have implications for delaying menopause. "We know that the timing of menopause is influenced by how many egg cells a female has," he said. "Interventions that slow the loss of egg cells from the ovaries could delay premature menopause. As well as prolonging female fertility, such a treatment could have the potential to reduce menopause-associated health conditions, such as osteoporosis and heart disease."

The research was supported by National Health and Medical Research Council, Cancer Council Victoria, the Victorian Cancer Agency, the US Leukemia and Lymphoma Society, the US National Cancer Institute, the American Cancer Society, and the Victorian Government.

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Story Source:

The above story is reprinted from materials provided by Walter and Eliza Hall Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jeffrey?B. Kerr, Karla?J. Hutt, Ewa?M. Michalak, Michele Cook, Cassandra?J. Vandenberg, Seng?H. Liew, Philippe Bouillet, Alea Mills, Clare?L. Scott, Jock?K. Findlay, Andreas Strasser. DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa. Molecular Cell, 2012; DOI: 10.1016/j.molcel.2012.08.017

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/nnnzydsczXM/120922085845.htm

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Obama 'Redistribution' Audio Clip Truncated By GOP

The 14-year-old audio clip circulated by the Mitt Romney campaign this week to attack Barack Obama as favoring "redistribution" of wealth was "deceptively edited," Democrats say, leaving out important context that Obama provided in his next breath.

In the clip Republicans are pushing around - and Romney now cites on the stump - then Illinois State Sen. Obama is heard speaking at a university conference in October 1998, appearing to endorse "redistribution" of wealth.

"I actually believe in redistribution, at least at a certain level, to make sure that everybody's got a shot," Obama is heard saying on the clip, which then abruptly ends.

In the full recording, obtained by NBC News, Obama continues to explain in the next sentence that he is speaking broadly about making city and state government more efficient in their use of resources - and endorses "competition" in the "marketplace."

"How do we pool resources at the same time as we decentralize delivery systems in ways that both foster competition, can work in the marketplace, and can foster innovation at the local level and can be tailored to particular communities," he says.

The edit of the last line out of the clip earned Romney and the Republican National Committee a "four pinocchios" rating by fact checkers at the Washington Post.

When asked about the newly revealed context, RNC spokeswoman Kirsten Kukowski insisted that Obama's comments still reflected a commitment to fostering government dependence.

"His policies over the past three and a half years bear that out," Kukowski said. "Under Obama we have increased our dependency on government with 47 million Americans on food stamps, record levels added to our debt and gutting work requirements for welfare. Instead of pro-growth policies, the Obama administration says they are relying on increased food stamps and unemployment to stimulate the economy."

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Source: http://news.yahoo.com/obama-redistribution-audio-clip-truncated-gop-164722632--abc-news-politics.html

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Something that's ?uncomfortable for doctors? - "NEW" PROSTATE ...

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There?s an interesting opinion piece on the Medscape web site today by Professor Eric Topol of the Scripps Translational Science Institute in La Jolla, California. His subject is ?Consumer-driven healthcare makes docs uncomfortable.?

Dr. Topol has long been an innovator in the world of medicine ? loved by some and hated by others. His premise (and remember that his piece is written primarily for physicians) is that we are at a tipping point in the evolution of individualized health care (because of consumer access to their individual health data) that is comparable to the effect of the Gutenberg printing press on the dissemination of religious knowledge because it made it possible for everyone to have and read their own bible. It changed the relationship between priest and parishioner just as mobile health data is going to change the relationships between doctors and patients.

Dr. Topol clearly thinks (as we do) that this is (a) inevitable and (b) potentially a good thing too. It obviously has ramifications way beyond prostate cancer ? but let?s not underestimate the potential impact on prostate cancer management.

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Source: http://prostatecancerinfolink.net/2012/09/21/something-thats-uncomfortable-for-doctors/

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$1.8 million grant supports investigation of psoriasis link to cardiovascular disease

[ Back to EurekAlert! ] Public release date: 20-Sep-2012
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Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University

Case Western Reserve University School of Medicine researcher to identify mechanistic link between two serious diseases

Armed with a new $1.8 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, dermatology researcher Nicole Ward, PhD, assistant professor of dermatology and neurosciences at Case Western Reserve School of Medicine, will lead a study examining the link between psoriasis and heart attack and stroke.

The work will advance research conducted earlier this year in Dr. Ward's lab. She and colleagues at the University Hospitals Harrington Heart & Vascular Institute, published a major discovery that psoriasis could cause the development of cardiovascular disease in mouse models. The team of researchers also found that aggressive treatment of the skin disease reversed the cardiovascular disease.

"Prior to our recent publication, the evidence linking these two diseases was entirely at the epidemiological level and didn't show mechanistic insight for why this occurred," says Dr. Ward, who is also a scientist with the Murdough Family Center for Psoriasis at University Hospitals Case Medical Center. "Our goal was to examine whether psoriasis influences cardiovascular disease. Psoriasis was previously thought of as a disease that severely affected skin appearance as well as the patient's quality of life. We now know it decreases a patient's life span by seven years."

Dr. Ward and colleagues will work to identify intrinsic changes in the skin cells and the subsequent cascade of events that leads to blood-clot formation in either heart attack or stroke. By identifying this trigger, the researchers hope to provide first-ever evidence that cell-specific events in psoriasis can be targeted for treatment.

This preclinical evidence will impact the approach to patient clinical care, as doctors will need to be more aggressive in monitoring for cardiovascular disease and other co-morbidities in those with moderate to severe-plaque psoriasis. By treating and keeping the skin disease in check, the risk for heart-related inflammation is reduced as well. In addition, they will conduct preclinical testing of the efficacy of current psoriasis medication on cardiovascular disease.

"Dr. Ward's research discovery is quite exciting," says Kevin Cooper, MD, professor and chair of the Department of Dermatology at Case Western Reserve School of Medicine and University Hospitals Case Medical Center, "It demonstrates for the first time that a mouse model of psoriasis exhibits a cardiovascular co-morbidity often seen in human psoriasis patients. Importantly, the basis of Dr. Ward's grant demonstrates that aggressively treating the skin disease improved the cardiovascular complications associated with psoriasis. The work supported by this grant will help to pinpoint how current therapeutics for psoriasis may also improve co-morbidities associated with chronic skin inflammation."

###

This research was funded by the National Institutes of Health, National Psoriasis Foundation, and the Murdough Family Center for Psoriasis.

About Case Western Reserve University School of Medicine

Founded in 1843, Case Western Reserve University School of Medicine is the largest medical research institution in Ohio and is among the nation's top medical schools for research funding from the National Institutes of Health. The School of Medicine is recognized throughout the international medical community for outstanding achievements in teaching. The School's innovative and pioneering Western Reserve2 curriculum interweaves four themes--research and scholarship, clinical mastery, leadership, and civic professionalism--to prepare students for the practice of evidence-based medicine in the rapidly changing health care environment of the 21st century. Eleven Nobel Laureates have been affiliated with the school.

Annually, the School of Medicine trains more than 800 M.D. and M.D./Ph.D. students and ranks in the top 25 among U.S. research-oriented medical schools as designated by U.S. News & World Report "Guide to Graduate Education."

The School of Medicine's primary affiliate is University Hospitals Case Medical Center and is additionally affiliated with MetroHealth Medical Center, the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, and the Cleveland Clinic, with which it established the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University in 2002.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 20-Sep-2012
[ | E-mail | Share Share ]

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University

Case Western Reserve University School of Medicine researcher to identify mechanistic link between two serious diseases

Armed with a new $1.8 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, dermatology researcher Nicole Ward, PhD, assistant professor of dermatology and neurosciences at Case Western Reserve School of Medicine, will lead a study examining the link between psoriasis and heart attack and stroke.

The work will advance research conducted earlier this year in Dr. Ward's lab. She and colleagues at the University Hospitals Harrington Heart & Vascular Institute, published a major discovery that psoriasis could cause the development of cardiovascular disease in mouse models. The team of researchers also found that aggressive treatment of the skin disease reversed the cardiovascular disease.

"Prior to our recent publication, the evidence linking these two diseases was entirely at the epidemiological level and didn't show mechanistic insight for why this occurred," says Dr. Ward, who is also a scientist with the Murdough Family Center for Psoriasis at University Hospitals Case Medical Center. "Our goal was to examine whether psoriasis influences cardiovascular disease. Psoriasis was previously thought of as a disease that severely affected skin appearance as well as the patient's quality of life. We now know it decreases a patient's life span by seven years."

Dr. Ward and colleagues will work to identify intrinsic changes in the skin cells and the subsequent cascade of events that leads to blood-clot formation in either heart attack or stroke. By identifying this trigger, the researchers hope to provide first-ever evidence that cell-specific events in psoriasis can be targeted for treatment.

This preclinical evidence will impact the approach to patient clinical care, as doctors will need to be more aggressive in monitoring for cardiovascular disease and other co-morbidities in those with moderate to severe-plaque psoriasis. By treating and keeping the skin disease in check, the risk for heart-related inflammation is reduced as well. In addition, they will conduct preclinical testing of the efficacy of current psoriasis medication on cardiovascular disease.

"Dr. Ward's research discovery is quite exciting," says Kevin Cooper, MD, professor and chair of the Department of Dermatology at Case Western Reserve School of Medicine and University Hospitals Case Medical Center, "It demonstrates for the first time that a mouse model of psoriasis exhibits a cardiovascular co-morbidity often seen in human psoriasis patients. Importantly, the basis of Dr. Ward's grant demonstrates that aggressively treating the skin disease improved the cardiovascular complications associated with psoriasis. The work supported by this grant will help to pinpoint how current therapeutics for psoriasis may also improve co-morbidities associated with chronic skin inflammation."

###

This research was funded by the National Institutes of Health, National Psoriasis Foundation, and the Murdough Family Center for Psoriasis.

About Case Western Reserve University School of Medicine

Founded in 1843, Case Western Reserve University School of Medicine is the largest medical research institution in Ohio and is among the nation's top medical schools for research funding from the National Institutes of Health. The School of Medicine is recognized throughout the international medical community for outstanding achievements in teaching. The School's innovative and pioneering Western Reserve2 curriculum interweaves four themes--research and scholarship, clinical mastery, leadership, and civic professionalism--to prepare students for the practice of evidence-based medicine in the rapidly changing health care environment of the 21st century. Eleven Nobel Laureates have been affiliated with the school.

Annually, the School of Medicine trains more than 800 M.D. and M.D./Ph.D. students and ranks in the top 25 among U.S. research-oriented medical schools as designated by U.S. News & World Report "Guide to Graduate Education."

The School of Medicine's primary affiliate is University Hospitals Case Medical Center and is additionally affiliated with MetroHealth Medical Center, the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, and the Cleveland Clinic, with which it established the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University in 2002.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-09/cwru-gs092012.php

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Chicago Teacher Strike Ends, But Schools Still ... - Yahoo! Finance

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Roughly 350,000 Chicago students are back in school Wednesday as the impasse between the Chicago Teachers Union and the city came to an end after a seven-day strike.

"We said that it was time ? that we couldn't solve all the problems of the world with one contract, and that it was time to suspend the strike," said Chicago Teachers Union President Karen Lewis.

Chicago Mayor Rahm Emanuel called the settlement an "honest compromise."

The deal contains concessions from both sides. A major compromise for teachers was agreeing to undergo evaluations based on students' standardized test scores, which they had opposed.

For onlookers in the private sector where evaluations are de rigueur, it seemed absurd that some of the highest paid teachers in the country did not want to be evaluated on the merits of student performance, says The Daily Ticker's Henry Blodget in the accompanying interview. Teachers in the nation's third largest school district earn an average annual salary of $76,000.

[Related: Chicago Teacher Strike Underscores One of the Most Important Issues of Our Time]

The terms of the three-year contract (which could be extended to four years) have not been made public, but here's what we do know:

  • Teachers will receive a 17% pay raise over the next four years, an annual increase of 4.4%.
  • The school day for elementary kids will be extended to 7 hours versus less than 6 hours before the strike.
  • Teachers will be evaluated based in part on student performance. This year and next, 25% of a teacher's evaluation will be based on standardized test scores. By 2014, roughly a third of a teacher's assessment will depend on student test scores.
  • The new contract still needs to be ratified by the union's 26,000 members, which could take up to several weeks.

While the deal settles the city's first teachers' strike in 25 years, education expert Pedro Noguera, a professor at New York University and director of the Metropolitan Center for Urban Education, says the new contract won't solve the city's failing school system, which has been under the guise of "reforms" for years.

"In the short term, [the teachers] clearly got what they wanted," says Noguera, who is also the author of "The Trouble With Black Boys ... And Other Reflections on Race, Equity and the Future of Public Education. The strike underscored that the "reforms that have been being pursued by Rahm Emanuel and Chicago Public Schools were really having an injurious impact on schools and on children."

Mayor Emanuel has been pushing to close failing schools, open new charter schools and base teacher evaluations on test scores. Chicago has closed more schools than any other school district, says Noguera, adding that all these ideas began when Arne Duncan, U.S. Secretary of Education, sat at the helm of the Chicago Public Schools Board during the last decade.

[Related: Obama Education Chief: Complacency Caused U.S. to Slip to 16th in World College Graduation Rates]

Noguera says the strike brought attention to the ineffectiveness of these reforms. "The conditions in the schools are the issues that don't get enough attention, but were being raised by the teachers," he adds.

The conditions Noguera refers to include large class sizes, lack of playgrounds and no air conditioning, which can be distracting for students on days when temperatures hit 100-plus degrees. These are not good learning conditions, Noguera says. Student poverty also plays a large role in a child's ability to learn. More than 80% of students in Chicago Public Schools come from low-income households.

"The strike might not be the best way to raise those issues," says Noguera. "But if something is not done to improve learning conditions you are not going to see better outcomes."

Tell us what you think!

More from The Daily Ticker

Why Amazon's State Sales Tax Could Be Good for Customers

Why the Treasury Dept. Won't Sell Its GM Stake Before November

Are 47% of Americans Government Moochers?

U.S. Files WTO Complaint Against China: Is Detroit Really at a Disadvantage?

Source: http://finance.yahoo.com/blogs/daily-ticker/chicago-teacher-strike-ends-failing-schools-remain-pedro-143611409.html

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Entertaining With Excellent China | Tongshu Articles

Entertaining With Excellent China

View PDF | Print View | Html View--> Author (mindicarico556). 36 | Word Count: 572 |--> Submitted on Tue, 18 Sep 2012

If you are somebody that enjoys entertaining, it is likely that you considered the possibility of throwing a dinner party in the past. These can range from very simplistic parties where you will have an intimate gathering of family and friends to more extravagant gatherings that will require quite a bit of work on your part. Of course, all of us like to be well fed during such a party but there are many things that also go into the evening event that take place behind the scenes. Here's how to make sure that you throw the perfect dinner party that your guests are going to love.

One important part of the party that should not be overlooked is the setting of the table. This can be done in any number of different ways and you might be surprised with the diversity of what you can do, even if you have one particular style that you use. It may be to your benefit to look for some Juliska dinnerware or perhaps some Jan Barboglio designs that will help you to feel comfortable with what you're doing. One thing is certain, having the table set properly is going to help everybody enjoy the meal all that much more. Here are some specifics of what you can do.

The first thing which needs to be considered when setting the table is the centerpiece. The reason why that is the case, is because it is going to set the mood for the entire table. There are some centerpieces that can be purchased in your local area but you may also want to consider designing one as well. Just make sure that it is large enough to really set off a dinner table without being so large that it keeps people from seeing each other because it is blocking the view.

Most people are aware of the fact that forks go on the left and knives and spoons go on the right. One easy way for you to remember this if you always need to look it up in advance is the fact that four and left both have four letters. Incidentally, knife, spoon and right all have five letters. If you are going to be setting out multiple kinds or forks, have the larger forks closer to the plate and then the smaller forks trailing according to size away from the plate.

Now that the table is ready, make sure that you give it a dry run in advance of throwing the party. You may also want to set it up during the day so that it will be ready before anyone arrives. You can then concentrate on the food and the other aspects of the evening that are going to help to make it special. Look for the perfect wine complement in advance and the mood is going to be right for the theme of the party. The more thought that you put into a party in advance, the more people are going to enjoy what it offers to them. It is something they will talk about for many years to come.

?

About the Author

The author of this article entertains guests regularly and uses her Juliska dinnerware whenever she can. Those and Jan Barboglio designs are her favorite for entertaining.


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  • Source: http://www.tongshu.net/home-family/entertaining-with-excellent-china.html

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    This Week's Visual Art, Sept. 19-23: Gallery Openings, News, And ...

    MTV RE:DEFINE?at?The Goss-Michael Foundation?? Septemeber 13-22.1405 Turtle Creek Blvd., Dallas, TX 75207.

    There?s a tendency, and not just in Dallas, to use art as an excuse for something else ? an overt display of wealth or societal clout, a prominent display of munificence ? so much so that the work itself is consumed by the context of its utilization. We wonder, what is the import, value, and meaning of a work of art when its real use and function has become an excuse for the pageantry of conspicuous transferring of the wealthy?s excess capital to the coffers of a charity? Can we really claim that the work has a life, an existence outside of this context, and can it be viewed as such, as it sits on the wall, waiting for the activity that has brought it into the space for auction? How do we consider a thing when we know it has been vetted and selected precisely because of the qualities that lend it a consumptive desirability, prepped like a piece of fish on a plate in a photographer?s studio before a magazine shoot?

    And once it is bought and shipped and hung in the confines of someone?s sleek and generically modern domicile, what is then? Can it shake the echo of its traumatic distribution through the mechanisms of the economic machine that is, at least in part, its raison d? ?tre? In this context it seems that all work becomes like Duchamp?s Fountain, only it is not a banal accessory of daily life elevated to art through the recontextualizing power of the gallery space, but rather the reduction of each work of art to banal accessory through the recontextualizing power of the action block.

    More and more it seems that art appears in Dallas as a kind of prop, caught up in the context of various forms of ulterior performance. And this co-option of the product of the labor of the artist into the larger pageantry of an orchestrated performance, which uses so-called works of art to grist the gears of its own self-serving and cursory aims, is hardly limited to the high-end auctions or A-list social bangers. Groups that stage ?art events,? superficial soir?es that cast the display of art as one of a number of sideshows, sideshows that don?t so much entertain as they help extract from the presence of art work a kind of feeling of cool, or mood of cultural presence.

    We also have of late the proliferation of consciously engendered art ?scenes,? roving bands of party-minded youths co-opting the language, dress, and attitude from avant-gardes of the past ? plucked with the haphazard algorithmic association of a Google image search ? scenes-stagers who become ends in themselves, to whom art is merely a means by which these well-meaning enthusiasts can live out their bohemian fantasies.

    Then we have the pseudo-intellectual hucksters who eschew commitment to real curatorial rigor and vision for the jesterly performance, the art event that cultivates enthusiasm and acclaim around the cult of the fool. In fact, art is so often reduced to accessory ? in the auctions and art parties, in the hyped-scenesterism and anti-intellectual sophistry ? that we can hardly claim any idea what art?s actual purpose and role is anymore. Perhaps that?s precisely the point, that just as painting has supposedly died, now art has too. Is it silly, uneducated, foolish, or embarrassing to even assert that art has a role or purpose any more?

    Yet, given the great groaning of the current political moment, the shrapnel fragmentation of the contemporary world, the blurring of the boundaries of reality between the natural and the digitally-produced, the unreliability of our perceptions, the dizzying senselessness or dubious nature of the structures of meaning that have given shape to culture and society for centuries and yet now appear inadequate for our day ? given all of this, where is the urgency for grappling with the real questions we face? Where is the hope that fuels and gives life to our grappling, that bolsters the resolve of our artists, our poets, our thinkers? Where are the sane, sensible art spaces? I think I can say there are only a handful, places like The Reading Room, The Free Museum of Dallas, Fort Worth Contemporary Arts, and the third floor of The Power Station as it hosts its video art retrospective.

    But what has otherwise happened is that we suffer from a cultural bends, a thinning of the blood brought on by the desire to seek relief from the unbearable pressure of an incomprehensible contemporary life. We have risen to the surface too quickly, and that?s where we now lie, stricken and helpless and breathless, on the surface of things.

    Here are the gallery openings:?

    ?Y?UTOPIAS: An Almanac (of sorts) of Sustainable and Off-The-Grid Living in Texas? by Janeil Engelstad, at The Reading Room ? September 22 : 7-9 p.m.?3715 Parry Avenue,Dallas, Tx 75226.

    Spend some time on Engelstad?s website, particularly her MAP project, and don?t miss this show.

    ?Four Nights, Four Decades??at?The Power Station???September 20 at 7:30 p.m. 3816 Commerce Street, Dallas, TX 75226:

    The retrospective culminates Thursday night with that hard to categorize decade: the aughts. But the capstone of the series comes with rare exhibition of Anthony McCall?s ?Line Describing a Cone??at Angstrum this Saturday. Here?s a taste of what?s in store, and here?s more on te event.

    ?Duality Reality? by Jordan Castilleja, Katherine Habeck, Justine McGregor, Lauren McKillip, Taylor Smith, Emmie Skinner, Floy Giadarski, Andrew Piepenburg, Eric Docherty, and Chris SooHoo, at the Ro2 Art Downtown Gallery ? September 20 : 6:00 PM ? 8:00 PM;?1408 Elm Street, Dallas, Tx 75202.

    ?I Can See Myself ? a collection of self portraits by Texas artists? at Kettle Art ? September 20, 7-10 p.m. 2714 Elm St., Dallas, TX75226.

    ?A Rebirth in Every Cell? by Dr. Samuel Lam, at Trenz Gallery ? September 20 : 7:00 PM ? 8:00 PM;?1315 East Levee Street, Dallas, Tx 75207.

    ART BEEF: soft opening by Art Beef ? September 22, 7-11 p.m. 1802 Greenville Ave. Dallas, TX 75206.

    ?No WayUp But Down? New Art By Bruce Lee at Might Fine Arts ? September 22, 6-9 p.m. 419 N. Tyler, Dallas, TX 75208.

    ?Feed Bag? By In Cooperation With Muscle Nation. A Collective at The Lemon Bar ? September 22: 7-9 p.m.3699 McKinney Ave. Ste 106B,Dallas,TX75206.

    ?The Cycle Of The Fig Tree? by Carlos Cazares, at Mokah Art Gallery ? September 22 : 6:00 PM ? 9:00 PM;?2803 Taylor Street,Dallas,Tx 75226.

    ?100 Years of Oak Cliff Art??by Chris Bingham, Robert Bittle, Katherine Colin, Ray-Mel Cornelius, Richard Doherty, Bryan Florentin, Art Garcia, Bryan Gooding, Donna Harris, Kyle Hobratschk, Duke Horn, Jeffrey Jensen, Tray LaCaze, Rosie Lindsey, David Lyles, Cynthia Maute, Lyndon Mitchell, Charley Mitcherson, Kim Cadmus Owens, Larry Pile, James Schroeder, Kitty Alice Snead, Tamara White, Scott Winterrowd, and Debra Witter, at the?Turner House?of the Oak Cliff Society of Fine Arts ? September 22 : 6:00 PM ? 8:00 PM;?401 North Rosemont Avenue, Dallas, Tx 75208.

    ?Focal Point??by Edward Ruiz, Eric Trich and Kristin Swenson, at the?WAAS Gallery?- September 22 : 7:00 PM ? 11:00 PM;?2722 Logan Street,Dallas,Tx 75215.

    DADA?s?Fall Gallery Walk?- September 22 : 2:00 PM ? 8:00 PM

    ?49th Annual Members Exhibition? at the Southwest Watercolor Society ? September 22 : 6:00 PM;?PFAMILY ARTS,4017 Preston Rd. #544, Plano, Tx 75093

    Image at top: Mat Collinshaw, Last Meal On Death Row, Texas (Martin Vegas), 2011 (detail) 64?46 cm C-Print framed with Red Grandis timber, rubbed back with black lacquer finish (Work included in this weekend?s MTV Re:Define auction at The Goss-Michael Foundation.

    Source: http://frontrow.dmagazine.com/2012/09/this-weeks-visual-art-sept-19-23-gallery-openings-news-and-reviews/

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    Creative Small Business Advertising: Car Wraps | Queensland Car ...

    Large businesses have an advantage when it comes to branding because they have a substantial marketing budget that small businesses typically lack. Large corporations get their brands out to the consumer through expensive ad campaigns, but most small business owners cannot afford those flashy campaigns. If you own a small business or are starting one up in the near future, you will have to get creative if you want to get your brand out to the masses.

    car wrapping is not only a creative marketing opportunity, but it is an affordable option for most small businesses. This simply means you go to a professional service to turn your vehicle into a moving billboard. An actual billboard over a popular highway may be out of your budget at this point, but you can still get that level of exposure in your local community.

    Wherever the vehicle goes, you gain exposure for your brand. You can guarantee that others will see your vehicle and then think of your company when they need to hire a service or purchase a product related to your business. Stationary billboards grab attention with flashy colors and interesting text, but they are limited to the people that drive by their location. Vehicles turned into billboards can be just as interesting in design and just as eye-catching, but they have the benefit of moving around for greater exposure.

    The simplest way to get professional benefits from car wraps is to use them on your work vehicles. You have probably noticed company logos and professional designs on cars while you were out on the road, right? Your eye is turned by these signs, even if you have seen them a million times. If you happen to need services or products offered by a company and their moving billboard was in front of you at a stop light, there is a good chance you would give them a call.

    Geek Squad is one popular brand that maximizes exposure through on-vehicle branding. Their cars are easily identifiable, so they are essentially tools for branding. Most consumers recognize those cars when they see them, and it reminds them that the Geek Squad is there when needed. Best Buy would not waste marketing dollars on car wraps if they were not pulling in some profit.

    You don?t even need a company vehicle to make use of car wrapping. It is now quite common for business owners to have private vehicles wrapped for professional gain. You may want to go more flashy and creative when coming up with a design for a wrap on your personal vehicle, since you have more freedom of expression on a private vehicle. If you do have a company vehicle to wrap, you may still choose to decorate your private vehicle in a more elaborate coordinating design.

    Local advertising is more difficult today, since many of the traditional forms of marketing have become useless due to technological advances. For example, you may not get much response from an ad in a local newspaper, since so many people get their news over the internet rather than from the local paper. Most companies are now advertising more online, but creative offline campaigns can still be effective. Car wraps allow you to make one investment and achieve long term results without relying on technology.

    Learn more about boat graphics.find out all about car signage and what it can do for you.

    Source: http://www.qldlandcareconference.com/muscle-cars/creative-small-business-advertising-car-wraps

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    Directors Guild changes nomination date to get out of Oscar's way

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